Table 1.
Patient and transplant characteristics
| Characteristics | All patients n=988 |
IMI patients n=22& |
Non-IMI patients n= 966 |
|---|---|---|---|
| Age, median (range) | 54 (18–75) | 53 (31–68) | 54 (18–75) |
| Gender Male, n (%) | 590 (60) | 10 (45) | 580 (60) |
| Diagnosis | |||
| Acute myeloid leukemia | 351 (36) | 5 (23) | 346 (36) |
| Acute lymphoblastic leukemia | 85 (9) | 5 (23) | 80 (8) |
| Acute leukemia- other | 16 (2) | 0 (0) | 16 (2) |
| Chronic myelogenous leukemia | 25 (3) | 0 (0) | 25 (3) |
| Lymphoid malignancy | 248 (25) | 8 (36) | 240 (25) |
| Multiple myeloma | 103 (10) | 1 (5) | 102 (11) |
| Myelodisplastic syndrome | 127 (13) | 3 (14) | 124 (13) |
| Myeloproliferative neoplasm | 33 (3) | 0 (0) | 33 (3) |
| Previous autologous transplant, n (%) | 181 (18) | 3 (14) | 178 (18) |
| Conditioning, n (%) | |||
| Chemotherapy-based | 537 (54) | 8 (36) | 529 (55) |
| TBI-based | 451 (46) | 14 (64) | 437 (45) |
| Donor type, n (%) | |||
| Matched related | 319 (32) | 4 (18) | 315 (33) |
| Mismatched related | 9 (1) | 0 (0) | 9 (<1) |
| Matched unrelated | 364 (37) | 8 (36) | 356 (51) |
| Mismatched unrelated | 142 (14) | 6 (27) | 136 (14) |
| Cord blooda | 154 (16) | 4 (18) | 150 (15) |
| Sourceb , n (%) | |||
| - Bone marrow | 34 (3) | 1 (5) | 33 (3) |
| - Peripheral blood | 798 (81) | 17 (77) | 781 (81) |
| - Cord blooda | 154 (16) | 4 (18) | 150 (16) |
| Manipulation, n (%)c | |||
| - Unmodified | 349 (35) | 7 (32) | 342 (35) |
| - CD34+ selection | 485 (49) | 11 (50) | 474 (49) |
| - In vivo TCD (ATG or Campath) | 154 (16) | 4 (18) | 150 (16) |
Abbreviations: IMI, invasive mold infection; TCD, T-cell depletion; TBI, total body irradiation.
a
Includes patients receiving cord blood transplantation with support of haploidentical CD34+selected grafts.
b
Two patients received bone marrow and peripheral blood as part of a clinical trial.
c
Cord blood not included.
&
Includes the 21 patients diagnosed during follow-up and one additional patient diagnosed post-mortem