TABLE 1.
Gene variants discussed in this review
| Gene | Chr Location | Function | Imaging | Phenotype (language/reading) |
References |
|---|---|---|---|---|---|
| BDNF | 11p13 | Neuronal survival Neuronal proliferation Synaptic growth |
fMRI | Reading | Jasinska et al. (2016) |
| C2orf3/GCFC2/MRPL19 | 2p11-q11.2 | Unknown | MRI DTI |
Reading |
Eicher et al. (2016) Scerri et al. (2012) |
| CMIP | 16q23.2-q23.3 | T-cell signaling | MRI | Reading | Skeide et al. (2016) |
| COL4A2 | 13q34 | Type IV collagen subunit encoding | MRI | Reading | Skeide et al. (2016) |
| COMT | 22q11.21 | Dopamine metabolism | fMRI | Reading | Landi et al. (2013) |
| NRSN1 | 6p22.3 | Neurite growth | MRI | Reading | Skeide et al. (2016) |
| ROBO1 | 3p12.3 | Neuronal migration Axon guidance | MEG | Reading | Lamminmäki et al. (2012) |
| CCDC136/FLNC | 7q32.1 | Unknown | MRI | Reading/Language | Gialluisi, Guadalupe, Francks, and Fisher (2017) |
| DCDC2 | 6p22 | Neuronal migration | MRI fMRI rsMRI EEG DTI |
Reading/Language |
Cope et al. (2012) Czamara et al. (2011) Darki et al. (2012) Darki et al. (2014) |
| Cilia |
Marino et al. (2014) Meda et al. (2008) |
||||
| DYX1C1 | 15q21.3 | Neuronal migration | MRI | Reading/Language | Darki et al. (2012) |
| Cilia | Darki et al. (2014) | ||||
| FOXP2 | 7q31 | Transcriptional regulation Neurogenesis | MRI fMRI PET |
Reading/Language |
Belton et al. (2003) Liegois et al. (2003) Pinel et al. (2012) Skeide et al. (2016) Vargha-Kadem et al. (1998) Watkins et al. (2002) |
| KIAA0319 | 6p22 | Neuronal migration | MRI fMRI rsMRI EEG DTI |
Reading/Language |
Wilcke et al. (2012)
Czamara et al. (2011) Darki et al. (2012) Darki et al. (2014) Eicher et al. (2016) Pinel et al. (2012) |
| RBFOX2 | 22q12.3 | Alternative exon splicing regulation | MRI | Reading/Language | Gialluisi et al. (2017) |
| SETBP1 | 18q12.3 | DNA replication, apoptosis, transcription, nucleosome assembly | fMRI | Reading/Language | Perdue et al. (2019) |
| SLC2A3 | 4q32.1 | Neural glucose transport regulation | EEG rsMRI DTI |
Reading/Language |
Roeske et al. (2011) Skeide et al. (2015) |
| ACOT13/THEM2 | 6p22.3 | Cell proliferation | MRI DTI |
Reading/Language |
Eicher et al. (2016) Pinel et al. (2012) |
| CNTNAP2 | 7q35 | Cell adhesion Voltage-gated channels | MRI fMRI DTI |
Language |
Dennis et al. (2011)
Koeda et al. (2015) Skeide et al. (2016) Tan et al. (2010) Udden et al. (2017) Whalley et al. (2011) |
Note. Publications focused on patient populations and/or individuals with disorders other than SRD and DLD were excluded from our review.