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. 2019 Dec 12;14:9837–9854. doi: 10.2147/IJN.S228462

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© 2019 Kar et al.

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Effect of various hydrogel formulations on collagen synthesis and re-epithelialization. 12 days treated skin samples around the wound area were taken, and 5µ thin samples were cut by microtome for histo-pathological examination. (A) Representative photomicrographs of Masson trichrome-stained skin section showing enhanced collagen synthesis, firm-differentiated epithelium, and no visible inflammation or infection on HG-Ag-EGCG-treated sections while the control group showed more void spaces with loose crust. (B) Hematoxylin and eosin (H&E) stain shows HG-Ag-EGCG-exposed group has successful reepithelialization, granular tissue formation with enhanced neovascularization and densely packed keratinocytes (yellow arrows) (n = 3, scale bar 100 µm).