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. Author manuscript; available in PMC: 2019 Dec 16.
Published in final edited form as: Cell Rep. 2019 Dec 3;29(10):3073–3086.e5. doi: 10.1016/j.celrep.2019.11.010

Figure 6. Effector T Cells Require IL-27 Signaling for Sjögren Syndrome-like Inflammation in NOD Mice.

Figure 6.

(A and B) Quantification of inflammation of male lacrimal (A) and female salivary (B) glands from 10-week-old NOD, NOD.Il27−/−, and NOD.Il27ra−/− mice. Symbols represent individual mice, and lines are medians. p < 0.0001 (A) and p = 0.0014 (B) by Kruskal-Wallace test with Dunn’s post-test p values as indicated. *p < 0.05, **p < 0.01, and ***p < 0.005.

(C) Graph depicts quantification of inflammation of male lacrimal glands from 21-week-old NOD and NOD.Il27ra−/− mice. Symbols represent individual mice, and lines are medians. Boxed symbol represents diffuse inflammation with foci so numerous that they coalesced, preventing accurate enumeration. *p < 0.05 by Mann-Whitney test. Histology images are H&E-stained tissue sections representative of NOD (top) and NOD.Il27ra−/− (bottom) mice and demonstrate the characteristic focal inflammatory cell infiltrates that are more abundant in NOD lacrimal glands. Scale bar is 1 mm.

(D) Quantification of lacrimal gland inflammation in male NOD-scid recipients of sorted effector T cells (CD8+ and CD4+CD25− sorted together) from spleens of male NOD or NOD.Il27ra−/− mice. Symbols represent individual mice pooled from two independent transfers. Lines are medians. ***p < 0.005 by Mann-Whitney test.