A) Cumulative BSA release from 2% M-CHT spheres (blue circles) and spheroids (62% deformation) (red squares), up to 216
hours, with a zoomed-in view for the initial 2 hours (n = 3). Values plotted are the mean +/− error for 3 samples. Both
experimental and curve fits using the Korsmeyer-Peppas equation are presented in the figure (lines with the same color of the
corresponding symbols). Statistical significance of p < 0.05 (*), p < 0.01 (**), and p < 0.001 (***) are
represented for time-points when applicable. (B) Numerical modelling studies for the release of a compound from spherical versus
spheroidal particles with varying particle height. Variation in height of spheroidal particles (¾, ½, and ¼)
is presented relative to spherical particles, corresponding to 1. Adapted from Bjørge et.al [64]. (Reproduced with permission from the Royal Society of Chemistry, Copyright 2018.)