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. Author manuscript; available in PMC: 2019 Dec 16.
Published in final edited form as: Circ Res. 2015 Jan 30;116(3):515–530. doi: 10.1161/CIRCRESAHA.116.305097

Figure 6. 1st and 2nd coronary vascular population in neonatal heart.

Figure 6.

Apln-CreER, induced at E10.5, labeled fetal coronary VECs with Cre-activated RFP expression. In the P7 postnatal heart, VECs were present throughout the myocardial wall, as demonstrated by immunostaining for the VEC-selective marker FABP4 (middle panel), but the RFP lineage tracer of fetal VECs was only observed in the outer myocardial wall (left panel). The FABP4+RFP+ VECs, descended from fetal VECs, are designated the 1st coronary vascular population (CVP; red pseudocolor, right panel) while the remaining FABP4+RFP− VECs, formed de novo in the postnatal heart, are designated the 2nd CVP (green pseudocolor, right panel). Bar = 1 mm.