Table 2.

Sensitivity, specificity, NPV and PPV of FIT for CRC and adenoma within TWW, NG12 and DG30 pathways

CRC	TWW (N=612) (95% CI)	NG12 (N=519) (95% CI)	DG30 (N=79) (95% CI)
Sensitivity	86.84% (71.91% to 95.59%)	84.85% (68.1% to 94.89%)	100% (47.82% to 100%)
Specificity	82.23% (78.85% to 85.27%)	81.28% (77.52% to 84.65%)	91.89% (83.18% to 96.97%)
NPV	98.95% (97.66% to 99.53%)	98.75% (97.23% to 99.44%)	100%
PPV	24.44% (20.69% to 28.63%)	23.63% (19.57% to 28.01%)	45.45% (27.9% to 64.22%)

Adenoma	TWW (N=612) (95% CI)	NG12 (N=519) (95% CI)	DG30 (N=19) (95% CI)
Sensitivity	30.69% (21.9% to 40.66%)	30.77% (21.51% to 41.32%)	25.00% (3.19% to 65.09%)
Specificity	79.65% (75.89% to 83.06%)	78.8% (74.82% to 82.79%)	86.48% (75.27% to 92.44%)
NPV	85.32% (83.53% to 86.96%)	87.17% (82.13% to 86.01%)	91.43% (87.61% to 94.15%)
PPV	22.96% (17.51% to 29.51%)	23.93% (18.01% to 86.01%)	16.66% (5.02% to 43.1%)

CRC, colorectal cancer; FIT, faecal immunochemical test; NPV, negative predictive value; PPV, positive predictive value; TWW, 2-week wait.