Table 9.

Per protocol analysis for level of pain.

Week	Pain at rest				Pain during activity				Pain during the night
	Intervention group, mean	Control group, mean	Model estimated difference (95% CI)	P value	Intervention group, mean	Control group, mean	Model estimated difference (95% CI)	P value	Intervention group, mean	Control group, mean	Model estimated difference (95% CI)	P value
1	4.98	5.54	0.54 (–0.15 to 1.23)	.13	5.71	5.65	–0.20 (–0.64 to 0.68)	.95	5.95	6.11	0.16 (–0.55 to 0.87)	.65
2	4.37	5.38	1.08 (0.38 to 1.77)	.002	4.94	5.84	0.99 (0.33 to 1.66)	.003	5.20	6.01	0.90 (0.19 to 1.61)	.01
3	4.05	5.05	1.01 (0.30 to 2.80)	.001	4.65	5.16	0.63 (0.04 to 1.30)	.06	4.91	5.98	1.09 (0.38 to 1.81)	.002
4	3.31	4.59	1.26 (0.56 to 1.96)	<.001	3.83	5.08	1.34 (0.68 to 2.00)	<.001	4.04	5.21	1.18 (0.47 to 1.89)	.001