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. 2019 Nov 20;11(22):10284–10300. doi: 10.18632/aging.102456

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Copyright © 2019 Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Erianin showed toxicity toward liver cancer cells. (A) Erianin reduced HepG2 and SMMC-7721 cell viability in a dose-dependent manner after a 24-h treatment. (B) Erianin significantly inhibited the formation of HepG2 and SMMC-7721 cell colonies (crystal violet staining, n = 6). (C) Erianin inhibited HepG2 and SMMC-7721 cell migration (migration assay, n = 6; 4× magnification, scale bar: 200 μm). (D) Erianin enhanced caspase-3, -8, and -9 activation in HepG2 and SMMC-7721 cells. Data are expressed as percentages relative to the corresponding control cells and as mean ± SD (n = 6). *P < 0.05, **P < 0.01, and ***P < 0.001 vs control cells. (E) Erianin increased the G2/M phase proportion within the cell cycle distribution (n = 6). (F) Erianin induced liver cancer cell apoptosis (n = 6).