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. 2019 Nov 26;11(22):9982–9999. doi: 10.18632/aging.102356

Figure 8.

Figure 8

Image showing the underlying mechanism of how hsa_circ_0000515 is involved in the progression of cervical cancer. Hsa_circ_0000515 acts as a ceRNA of miR-326 to upregulate ELK1, thereby resulting in promotion of cervical cancer cell proliferation and invasion, and inhibition of apoptosis and autophagy, as reflected by up-regulated PCNA, MMP-9 expression, and down-regulated LC3 expression.