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. 2019 Dec 10;11:347. doi: 10.3389/fnagi.2019.00347

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Copyright © 2019 Chen, Huang, Yang, Ye, Guo, Qin, Luo, Li, Ye, Zhang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Local efficiency of the six subnetworks. Significantly decreased local efficiency in the FPN in WMH-CIND subjects compared with WMH-NC subjects was found (ANOVA, P = 0.014; Bonferroni-corrected, P < 0.05/3). HCs showed higher local efficiency in the CON than WMH-NC and WMH-CIND subjects (ANOVA, P = 0.004; Bonferroni-corrected, P < 0.05/3). Abbreviations: HC, healthy control; NC, normal cognition; CIND, cognitive impairment without dementia; WMH, white matter hyperintensities; AUC, area under the curve; DMN, default mode network; FPN, fronto-parietal network; CON, cingulo-opercular network; SMN, sensorimotor network; ON, occipital network; CN, cerebellum network; G1 represents the HC group; G2 represents the WMH-NC group; and G3 represents the WMH-CIND group. ^∗ indicates a statistical difference between groups.