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. 2019 Dec 10;11:347. doi: 10.3389/fnagi.2019.00347

FIGURE 5.

FIGURE 5

Mediation analyses to explore relationships between WMH volumes, functional efficiency metrics and cognition in WMH-CIND subjects. (A) Association between PWMH volume and TMT-A score was significantly mediated by nodal global efficiency in the right DFC in the FPN (indirect effect: –0.26; 95% CI: –0.74, –0.01). (B) Indirect effect of PWMH on Stroop B performance was significantly mediated by nodal global efficiency in the left IPL in the FPN and the left DLPFC (total indirect effect: –0.42; 95% CI: –1.12, –0.05). (C,D) The nodal global efficiency in the left IPL and the right DFC in the FPN and the left DLPFC mediated the association between PWMH volume and Stroop A performance (total indirect effect: –0.52; 95% CI: –1.15, –0.08) and information processing speed (total indirect effect: –0.36; 95% CI: –0.96, –0.003). Abbreviation: CIND, cognitive impairment without dementia; WMH, white matter hyperintensities; PWMH, periventricular-white matter hyperintensities; DLPFC.L, left dorsolateral prefrontal cortex; DFC.R, right dorsal frontal cortex; IPL.L, left inferior parietal lobule; NE, nodal global efficiency; TMT-A, trail making test-A; Stroop B, Stroop Color and Word Tests B; IPS, information processing speed.