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. 2019 Mar 15;193(1):44–63. doi: 10.1007/s12011-019-01691-w

Fig. 1.

Fig. 1

Schematic representation of possible Se effects against AsIII-induced intoxication observed in recent studies. The three following basic Se effects (1) inhibition of As accumulation via formation of As–Se complexes, (2) activation of the Nrf2 factor, and (3) stimulation of GPx and TrxR activity most probably contribute to (4) a decrease in As-induced oxidative stress generation followed by (5) stabilization of mitochondria and blockade of As-induced apoptosis. In addition, stimulation of TrxR activity may contribute to (6) enhancement of As methylation capacity catalyzed by AS3MT. ↑, increased; ↓, decreased