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. 2019 Dec 10;13:72. doi: 10.3389/fninf.2019.00072

TABLE 1.

Volume atrophy was observed at the level of the whole brain (mm3) in APOE4HN mice relative to APOE3HN mice, and in select regions (volumes are reported for one hemisphere, as % of total brain volume).

Structure APOE4HN APOE3HN pFDR CI[1] CI[2] t Cohen d Diff (%)
(mean ± SD) (mean ± SD)
Temporal_association _cortex (%) 0.243 ± 0.028 0.274 ± 0.023 2.67E-02 −0.054 −0.009 −2.93 −1.21 −11.53
Cingulate_cortex _area_25 (%) 0.037 ± 0.002 0.042 ± 0.002 2.68E-04 −0.007 −0.003 −5.64 −2.34 −11.50
Cingulate_cortex _area_32 (%) 0.175 ± 0.011 0.195 ± 0.02 1.31E-02 −0.034 −0.008 −3.32 −1.37 −10.68
Cingulate_cortex _area_29b 0.032 ± 0.003 0.035 ± 0.003 1.48E-02 −0.006 −0.001 −3.26 −1.35 −10.46
Ventral_intermediate _entorhinal_cortex 0.096 ± 0.006 0.107 ± 0.003 3.20E-04 −0.015 −0.007 −5.51 −2.28 −10.30
Accumbens 0.434 ± 0.011 0.475 ± 0.011 2.43E-06 −0.051 −0.032 −9.04 −3.74 −8.67
Cingulate_cortex_area _24b_prime 0.054 ± 0.003 0.058 ± 0.004 1.61E-02 −0.008 −0.002 −3.22 −1.33 −7.91
Secondary_visual_cortex _mediomedial_area 0.192 ± 0.009 0.206 ± 0.016 3.26E-02 −0.024 −0.004 −2.82 −1.17 −6.85
Amygdalopiriform _transition_area 0.026 ± 0.002 0.028 ± 0.001 3.05E-02 −0.003 −0.001 −2.86 −1.18 −6.83
Primary_visual_cortex _monocular_area 0.409 ± 0.015 0.437 ± 0.032 2.38E-02 −0.049 −0.009 −3.01 −1.25 −6.60
Cingulate_cortex _area_29c 0.181 ± 0.008 0.193 ± 0.008 7.49E-03 −0.019 −0.005 −3.64 −1.51 −6.35
Dorsal_tenia_tecta 0.056 ± 0.003 0.059 ± 0.003 1.38E-02 −0.006 −0.001 −3.29 −1.36 −6.03
Cerebellar_cortex 4.553 ± 0.157 4.805 ± 0.205 1.10E-02 −0.405 −0.100 −3.43 −1.42 −5.25
Pontine_nucleus 0.126 ± 0.004 0.132 ± 0.006 4.00E-02 −0.010 −0.001 −2.71 −1.12 −4.35
Basal lateral amygdala 0.139 ± 0.005 0.145 ± 0.004 2.29E-02 −0.011 −0.002 −3.04 −1.26 −4.35
Middle_cerebellar _peduncle 0.159 ± 0.006 0.167 ± 0.005 1.79E-02 −0.012 −0.002 −3.17 −1.31 −4.31
Cingulate_cortex_area_30 0.294 ± 0.011 0.307 ± 0.009 1.90E-02 −0.022 −0.004 −3.14 −1.30 −4.24
Piriform_cortex 5.422 ± 0.077 5.554 ± 0.155 3.62E-02 −0.231 −0.033 −2.76 −1.14 −2.37
TotalBrain (mm3) 488.64 ± 11.21 522.44 ± 17.52 2.30E-04 −45.94 −21.66 −5.77 −2.39 −6.47