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. 2019 Dec 16;37(1):7. doi: 10.1007/s11095-019-2746-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Mechanism of QTc-interval prolongation. Serotonin reuptake inhibitors (SRIs) inhibit the hERG channel and therefore the I_kr (repolarizing potassium (K⁺) current) in the cardiomyocyte. This results in a delay of the ventricular repolarization time and therefore in a prolongation of the QTc-interval. Prolongation of the QTc-interval may result in cardiac arrhythmias such as TdP.