. 2019 Jul 4;18(2):349–362. doi: 10.1007/s40200-019-00419-w

Table 2.

Meta-analysis of effect of selenium supplementation on glycemic index

Glycemic index	Group (Number)^a	Number of Study	Pooled SMD (95% CI)	Model	Heterogeneity assessment
Glycemic index	Group (Number)^a	Number of Study	Pooled SMD (95% CI)	Model	I²	Q test	P value
FPG	I = 275	9	−0.03(−0.4,0.34)	Random	78.4%	37.10	<0.001
FPG	P = 260	9	−0.03(−0.4,0.34)	Random	78.4%	37.10	<0.001
Insulin	I = 256	9	−0.23(−0.6,0.14)	Random	76.6%	34.22	<0.001
Insulin	P = 243	9	−0.23(−0.6,0.14)	Random	76.6%	34.22	<0.001
HOMA-IR	I = 206	7	−0.3(−0.82,0.22)	Random	84.8%	39.56	<0.001
HOMA-IR	P = 201	7	−0.3(−0.82,0.22)	Random	84.8%	39.56	<0.001
HOMA-B	I = 130	4	−0.63(−0.89,-0.38)*	Fixed	0%	1.23	0.75
HOMA-B	P = 130	4	−0.63(−0.89,-0.38)*	Fixed	0%	1.23	0.75
QUIKI	I = 130	4	0.74(0.49,0.1)*	Fixed	0%	0.53	0.91
QUIKI	P = 130	4	0.74(0.49,0.1)*	Fixed	0%	0.53	0.91
HbA1c	I = 96	3	0.1(−0.63,0.84)	Random	83.1%	11.85	0.003
HbA1c	P = 82	3	0.1(−0.63,0.84)	Random	83.1%	11.85	0.003
Adiponectin	I = 465	4a	0.04 (−0.09,0.17)	Fixed	0%	0.40	0.94
Adiponectin	P = 406	4a	0.04 (−0.09,0.17)	Fixed	0%	0.40	0.94

I Intervention group, C Control group, FPG fasting plasma glucose, HOMA-IR homeostasis model of assessment-estimated insulin resistance, HOMA-B homeostasis model of assessment-estimated b cell function, QUICKI quantitative insulin sensitivity check index, HbA1c hemoglobin A1c

^a In one study, three different doses of adiponectin were used and we considered it as three studies

*Statistically significant