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. 2019 Dec 17;4:61. doi: 10.1038/s41392-019-0099-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — 8000 patients are planned to be screened through this trial to facilitate accrual to three substudies: ALCHEMISTEGFR (A081105; NCT02193282), ALCHEMIST-ALK (E4512; NCT02201992), and ALCHEMIST-nivo (EA5142; NCT02595944). In this trial, patients will have first undergone resection and completed standard adjuvant therapy. The patients with EGFR-mutated NSCLC will be randomized 1:1 to either erlotinib or placebo. The patients with ALK-rearranged NSCLC will be randomized 1:1 to crizotinib or placebo. The patients who are negative for EGFR or ALK mutations will be randomized to adjuvant nivolumab or observation for 1 year.