Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 16;9:19202. doi: 10.1038/s41598-019-55727-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Plasma levels of the 6 proteins quantified by Somalogic and linked to the molecular INCA network. Quantification of complement C3b (a), MAPK5 (b), cathepsin S (c) MMP1 (d), MMP7 (e) and F107B (f) by SOMAscan assay (left panels) and closest edges from the INCA network (right panels). Data are expressed in arbitrary units (AU) corresponding to relative fluorescence units for the SOMAscan assay. Data are presented as box-and-whisker plots showing median (line) and min to max (whisker). Statistical significance was determined by the Wilcoxon-Mann-Whitney test. ****P < 0.0001. Visualization of the INCA molecular subnetworks centralized on these molecules (right panels) for their interactions with other proteins quantified in the plasma of INCA patients. The colour of the nodes represents the log2FC of the comparison between the 2 groups of patients who died of CV causes (case) or alive (control) after 3 years, with red corresponding to high log2FC and blue to low log2FC (for details, see Supplementary Table S5). The size of the nodes is related to the centrality calculated from the INCA network model.