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. 2019 Dec 16;9:19162. doi: 10.1038/s41598-019-55631-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heme induces iPSC differentiation. iPSCs were treated with heme for 18 hours. (A) The number of cells positive for pluripotency markers (OCT-3/4, SSEA-4, and SOX-2) was determined using flow cytometry analysis. (B) The number of pluripotent cells decreased with increasing heme concentrations. The lowest percent of pluripotent cells was observed when heme was used at a concentration of 90 μM.