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. 2019 Dec 16;9:19162. doi: 10.1038/s41598-019-55631-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heme induces inflammation in cortical organoids (40 days in culture). Forebrain organoids were treated with heme for 8 hours and then NRG-1 for 18 hours. Representative images of organoids under heme and NRG-1 treatment (A) showing the expression of the chemokine CXCL-10, its receptor CXCR3, and BDNF in the VZ, SVZ, IZ and CP of the cortical organoids. The quantification of the staining intensity showed that heme significantly increased the expression of CXCL-10, CXCR3 and BDNF, while NRG-1 significantly reduced this effect (B) in all zones of the forebrain organoids.