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. 2019 Dec 10;10:2924. doi: 10.3389/fimmu.2019.02924

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Copyright © 2019 Goes, Dutra, Lösser, Hofbauer, Rauner and Thiele.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lack of Dkk-1 in osteocytes prevents periodontal bone loss. Maxillae of 12-week-old female Dkk1fl/fl;Dmp1:Cre-positive and -negative mice were analyzed by μCT. (A) Alveolar bone loss, (B) representative 3D reconstruction of hemimaxillae with and without ligature in buccal view, (C) trabecular bone volume per total volume (BV/TV), (D) bone mineral density, (E) trabecular number (Tb.N), and (F) trabecular thickness (Tb.Th) of hemimaxillae. (G) Serum levels of procollagen type 1 aminoterminal propeptide (P1NP) and (H) carboxy-terminal collagen cross-links (CTX-I) were assessed using commercially available ELISAs. Data represent the mean ± SEM of at least six animals per group. Statistical analyses were performed by ANOVA followed by the Bonferroni test. *P < 0.05 vs. respective normal hemimaxillae; ^#P < 0.05 vs. EP Cre-negative control.