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Study schedule. Before the experiment, the animals were allowed a 7-day adaptation period. Rats in all groups, except for those in the control group, were subjected to daily CIS for 3 h and administered the appropriate drug for 21 consecutive days. Body weights and food intake were recorded daily from the first day to the 21st day. The OFT was performed on day 20, and the SPT was performed on day 21. Rats were sacrificed on day 22.
