Table 2.

Factors associated with HT by multivariate logistic regression analysis.

	Model 1		Model 2		Model 3
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
NPR
Tertile 1	Reference		Reference		Reference
Tertile 2	1.521 (0.991–2.335)	0.055	0.946 (1.299–1.812)	0.837	1.017 (0.575–1.800)	0.953
Tertile 3	7.245 (4.525–11.600)	<0.001	7.839 (2.842–4.301)	0.005	2.000 (1.041–3.843)	0.037
Atrial fibrillation			2.627 (1.353–5.102)	0.004	2.514 (1.242–5.089)	0.010
Large infarct volume			7.839 (2.842–21.625)	<0.001	4.810 (1.679–13.780)	0.003
Baseline NIHSS			1.249 (1.175–1.329)	<0.001	1.256 (1.176–1.343)	<0.001
Anterior circulation					4.133 (2.068–8.261)	<0.001
Antiplatelet					0.213 (0.109–0.417)	<0.001

Model 1 was adjusted for age and gender. Model 2 was adjusted for the variables in model 1 plus the factors that had already been established as predictors of HT, including diabetes mellitus, atrial fibrillation, systolic blood pressure, large infarct volume, baseline NIHSS, anticoagulant and thrombolysis. Model 3 was adjusted for all the variables in model 2 plus the factors that significantly differed between the HT groups on the univariate analysis, including coronary heart disease, anterior circulation and antiplatelet. NPR, neutrophil-to-platelet ratio; HT, hemorrhagic transformation; OR, odd ratio; CI, confidence interval; NIHSS, National Institutes of Health Stroke Scale.