Table 2.
The ADC and the λ values found with both methods are reported, where the index I refers to the 2D gaussian fit method. The ADCII and the λII are the results obtained from the new model introduced in this work, mimicking all the physiological processes occurring during an experiment of FUS-induced blood-brain barrier opening for drug delivery (see Section 2.2). The parameter α is a proportionality factor used in the method II. Standard deviations are shown in bracket.
| Compound | Number of rats | ADCI (10−10 m2/s) | ADCII (10−10 m2/s) | α (10−2 a.u.) | λ I | λ II |
|---|---|---|---|---|---|---|
| Dotarem | 3 | 1.8 (0.6) | 3.2 (0.4) | 3.6 (0.5) | 1.6 (0.2) | 1.2 (0.1) |
| Gadovist | 3 | 1.5 (0.1) | 2.9 (0.3) | 2.2 (0.2) | 1.5 (0.5) | 1.2 (0.1) |
| MultiHance | 3 | 1.3 (0.3) | 1.8 (0.5) | 4.5 (3.5) | 1.5 (0.2) | 1.3 (0.2) |