Figure 4.

C33 dose-dependently inhibits cytokine production in DSS-induced colitis mice. WT mice were treated with C33 (10–400 mg/kg i.g.) or vehicle (10% ethanol) daily. Two days later, while the mice continued with the daily C33 treatment, they were also given normal drinking water or water containing 2.5% DSS for 7 days. At the end of experiments, blood was taken. Levels of IL-6 and TNF-α in plasma were measured by ELISA. Values are mean ± SD (n = 4). ^∗p < 0.05, the asterisks indicate a significant difference compared to the vehicle group.