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. 2019 Dec 3;2019:8239642. doi: 10.1155/2019/8239642

Figure 9.

Figure 9

Proposed mechanistic model of FA-97 protects against oxidative stress-mediated neuronal damage and apoptosis. Our findings demonstrated a scenario where FA-97 promotes the nuclear translocation of Nrf2 and the expression of its downstream target proteins HO-1 and NQO-1, to increase the SOD and GSH level, reduce the ROS and MDA level, and enhance the oxidant resistance, and eventually protects against oxidative stress-mediated neuronal cell apoptosis and scopolamine-induced cognitive impairment.