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Circulatory Tfh and Tfr cells in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV). (a) The gate strategy for circulatory Tfh and Tfr cells. The percentage and count of circulatory Tfh (b, c) and Tfr (d, e) cells and Tfh/Tfr ratios (f) in patients with AAV and healthy controls. (g) Mean fluorescence intensity (MFI) of FOXP3 in Tfh and Tfr cells. ∗∗P < 0.01. Tfh: T follicular helper cells; Tfr: T follicular regulatory cells.
