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. 2019 Dec 1;2019:6793596. doi: 10.1155/2019/6793596

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Copyright © 2019 Wilma Patrícia de Oliveira Santos Bernardes et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cytokine profile induced in Balb/c mice immunized with rSm16. Plasma from mice immunized with different vaccine formulations was obtained fifteen days after the third immunization for cytokine measurement. (a) IL-17, (b) TNF-α, (c) IFN-ɣ, (d) IL-6, (e) IL-2, and (f) IL-4 production in response to immunization with Freund's adjuvant only (open circles), alum only (open squares), rSm16/Freund's (black circles), or rSm16/alum (black squares). Cytokine levels were measured using the CBA Th1/Th2/Th17 kit. Mean ± SEM is presented in the graph. Significant differences observed using one-way ANOVA (d) or Kruskal-Wallis test (a–c,e, f) followed by Holm-Sidak's (d) or Dunn's (a–c,e, f) multiple comparison tests, using a correction for multiple comparison analysis, are shown in the figures. Statistically significant differences are denoted in each graph.