Table 2.
Protection induced by rSm16 immunization in mice.
| Worm burden | Protection (%) | Eggs/gram of liver (mean ± SD) | Egg/gram of intestine (mean ± SD) | |||
|---|---|---|---|---|---|---|
| Male | Female | Total | ||||
| Trial 1 | ||||||
| Freund's | 24 ± 6 | 21 ± 3.4 | 45 ± 8.1 | 10,604 ± 4,197 | nd | |
| rSm16/Freund's | 23 ± 4 | 22 ± 5.5 | 46 ± 9.8 | 0% | 20,151 ± 9,698 | nd |
| Alum | 25 ± 7.6 | 23 ± 7.5 | 43 ± 13 | 27,796 ± 18,446 | 22,176 ± 8,138 | |
| rSm16/alum | 20 ± 6.5 | 18 ± 5.7 | 40 ± 10 | 7.0% | 14,870 ± 10,373 | 16,353 ± 4,229 |
| Trial 2 | ||||||
| Freund's | 24 ± 8.6 | 22 ± 8 | 46 ± 18 | 40,088 ± 13,835 | 25,451 ± 11,114 | |
| rSm16/Freund's | 26 ± 6.4 | 21 ± 6 | 47 ± 14 | 0% | 56,091 ± 21,221 | 39,673 ± 23,297 |
| Alum | 21 ± 6.8 | 18 ± 6 | 39 ± 11 | 22,019 ± 6,143 | 16,009 + 6,931 | |
| rSm16/alum | 25 ± 6.5 | 21 ± 6.1 | 46 ± 12 | 0% | 23,806 ± 9,331 | 14,111 + 2,009 |
nd: not determined.