Table 1.
Summary of clinical characteristics of three HNSCC patient data sets in the study.
| Characteristic | Discovery dataset (N = 245) | Validation dataset (N = 244) | TCGA dataset (N = 489) | GSE65858 dataset (N = 270) | |
|---|---|---|---|---|---|
| Vital status, n (%) | Alive | 150 (61.2) | 128 (52.5) | 278 (56.9) | 176 (65.2) |
| Dead | 95 (38.8) | 116 (47.5) | 211 (43.1) | 94 (34.8) | |
| Age (years), n (%) | > = 60 | 132 (53.9) | 141 (57.8) | 273 (55.8) | 117 (49.3) |
| <60 | 113 (46.1) | 103 (42.2) | 216 (44.2) | 153 (56.7) | |
| Gender, n (%) | Female | 64 (26.1) | 66 (27.0) | 130 (26.6) | 47 (17.4) |
| Male | 181 (73.9) | 178 (73.0) | 359 (73.4) | 223 (82.6) | |
| Stage, n (%) | Stage I/II | 57 (23.3) | 37 (15.2) | 94 (19.2) | 55 (20.4) |
| Stage III/IV | 157 (64.1) | 171 (70.1) | 328 (67.1) | 215 (79.6) | |
| NA | 31 (12.6) | 36 (14.7) | 67 (13.7) | ||
| Grade, n (%) | G1 | 29 (11.8) | 32 (13.1) | 61 (12.5) | |
| G2 | 147 (60) | 144 (59.0) | 291 (59.5) | ||
| G3 | 59 (24.1) | 58 (23.8) | 117 (23.9) | ||
| NA | 10 (4.1) | 10 (4.1) | 20 (4.1) | ||
| Race, n (%) | White | 201 (82) | 216 (88.5) | 417 (85.3) | |
| Other_race | 34 (13.9) | 24 (9.8) | 58 (11.9) | ||
| NA | 10 (4.1) | 4 (1.7) | 14 (2.9) | ||
| ANGIOLYMPHATIC_INVASION, n (%) | Yes | 54 (22) | 61 (25) | 115 (23.5) | |
| No | 112 (45.7) | 104 (42.6) | 216 (44.2) | ||
| NA | 79 (32.2) | 79 (32.4) | 158 (32.3) | ||
| PERINEURAL_INVASION, n (%) | Yes | 72 (29.4) | 86 (35.2) | 158 (32.3) | |
| No | 98 (40) | 86 (35.2) | 184 (37.6) | ||
| NA | 75 (30.6) | 72 (29.5) | 147 (30.1) | ||
| Smoking_pack_years, n (%) | > = 40 | 82 (33.5) | 78 (32.0) | 160 (32.7) | 222 (YES, 82.2) |
| <40 | 61 (24.9) | 58 (23.8) | 119 (24.3) | 48 (NO, 17.8) | |
| NA | 102 (41.6) | 108 (44.2) | 210 (42.9) | ||
| ALCOHOL_HISTORY_DOCUMENTED, n (%) | Yes | 159 (64.9) | 165 (67.6) | 324 (66.3) | |
| No | 81 (33.1) | 73 (29.9) | 154 (31.5) | ||
| NA | 5 (2) | 6 (2.5) | 11 (2.2) | ||
| HPV_STATUS_P16, n (%) | Negative | 37 (15.1) | 32 (13.1) | 69 (14.1) | |
| Positive | 15 (6.1) | 15 (6.1) | 30 (6.1) | ||
| NA | 193 (78.8) | 197 (80.8) | 390 (79.8) |
HNSCC, head and neck squamous cell carcinoma; TCGA, the Cancer Genome Atlas.