Table 1.
Demographics and pulmonary arterial hypertension characteristics of patients included in registriesa
| Registry | US NIH22 | Switzerland20 | China16 | UK/ Ireland21 | France18 | US REVEAL24 | COMPERA23b | Czech Republic17 | Spain19 |
|---|---|---|---|---|---|---|---|---|---|
| Year of initiation | 1981 | 1998 | 1999 | 2001 | 2002 | 2006 | 2007 | 2007 | 2007 |
| Year of first data report | 1987 | 2015 | 2007 | 2012 | 2006 | 2010 | 2013 | 2014 | 2012 |
| Number of patients | 187 | 517 | 72 | 482 | 674 | 2525 | 587 | 191 | 866 |
| Study cohort | |||||||||
| Incidentc | ✓ | – | ✓ | ✓ | – | – | ✓ | – | – |
| Incident and prevalentd | – | ✓ | – | – | ✓ | ✓ | – | ✓ | ✓ |
| Age (years), mean (SD) | 36 (15) | 57 (16) | 36 (12) | 50 (17) | 50 (15) | 53 (14) | 71 (16)e | 52 (17) | 45 (17) |
| Female (%) | 63.1 | 60.0 | 70.8 | 69.9 | 65.3 | 79.5 | 60.3 | 65.5 | 71.0 |
| Time from first symptoms to diagnosis (months), mean (SD) | 24.4 (58.8) | NP | 26.4 (27.6) | 18 (9–36)e | 27f | 35.6 (37.9) | NP | 39 (48) | 42 (73) |
| 6MWD (m), mean (SD) | NP | 357 (137) | NP | 292 (123)g | 329 (109) | 366 (126) | 293 (126) | 324 (120) | 363 (120) |
| Haemodynamics, mean (SD) | |||||||||
| RAP (mmHg) | 10 (6) | 9 (4) | 12.8 (5.6) | 10 (6)h | 8 (5) | 9 (6) | 8 (5) | 10 (5) | 9 (5) |
| mPAP (mmHg) | 60 (18) | 48 (15) | 64.1 (17) | 54 (14)i | 55 (15) | 51 (14) | 44 (12) | 59 (63) | 54 (16) |
| PVR (Wood units) | NP | 9.4 (5.6)j | 20.4 (8.0) | 12.8 (6.3)k | NP | NP | 9.6 (5.5) | NP | 12 (6) |
| PVRI (Wood units·m2) | 26.2 (13.8) | NP | NP | 23.1 (10.1)l | 20.5 (10.2) | 21.1 (12.5) | NP | NP | NP |
6MWD, 6-min-walk distance; COMPERA, comparative, prospective registry of newly initiated therapies for pulmonary hypertension; mPAP, mean pulmonary arterial pressure; NIH, National Institutes of Health; NP, not presented; PVR, pulmonary vascular resistance; PVRI, pulmonary vascular resistance index; RAP, right atrial pressure; SD, standard deviation.
Pulmonary arterial hypertension-only where reported, idiopathic pulmonary arterial hypertension otherwise.
Austria, Belgium, Germany, Italy, the Netherlands, Switzerland, and UK.
Newly diagnosed patients.
Previously diagnosed patients.
Median (interquartile range).
SD not provided.
n = 260.
n = 439.
n = 457.
n = 440.
n = 395.
n = 355.