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. 2019 Dec 5;10:1289. doi: 10.3389/fneur.2019.01289

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Copyright © 2019 Ren, Hu, Jiang, Tan, Botchway, Amin, Lin, Geng and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of SIRT1 on OGD/R-induced cells apoptotic level. (A) Western blot results of SIRT1, Bax, Bcl-2, and GADPH. (B) Quantification analysis of SIRT1. Values are expressed as mean ± SEM (n = 3). SIRT1 Control vs. SIRT1 Over-expression, **P < 0.01; SIRT1 shRNA vs. SIRT1 shRNA Control, *P < 0.05. (C) Quantification analysis of Bax. SIRT1 Control vs. SIRT1 Over-expression, *P < 0.05; SIRT1 shRNA vs. SIRT1 shRNA Control, **P < 0.01. (D) Quantification analysis of Bcl-2. SIRT1 Control vs. SIRT1 Over-expression, *P < 0.05. (E) Quantification analysis of Bcl-2/Bax. SIRT1 Control vs. SIRT1 Over-expression, ***P < 0.001; SIRT1 shRNA vs. SIRT1 shRNA Control, *P < 0.05.