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. 2019 Dec 4;13:1261. doi: 10.3389/fnins.2019.01261

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Copyright © 2019 Lu, Moeini, Li, Lu, Damseh, Pouliot, Thorin and Lesage.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A,B) Typical 7-T MRI images, with coronal and axial views of the cortex. (C) Quantification of cerebral perfusion (ml/g/min) by MRI. (D) Averaged temporal response of oxy-hemoglobin (HBO) for all groups with 5-s stimulation (blue background). (E) Temporal dynamics of total hemoglobin (HBT) response to whisker stimulation. Stimulation lasted for 5 s, followed by a 15-s rest. (F) Averaged results for change in HBO (Δ[HBO](t)) and change in HBR (Δ[HBR](t)) over all mice. ^∗p < 0.05 and ⁺p < 0.1.