Table 1.

Major roles of white and subcutaneous adipose tissue miRNAs in inflammation

Adipose tissue microRNAs	Position	Main roles in inflammation	Ref
miR-150	SAT	Reducing inflammatory cytokines (such as TNF-α and IL-2) by targeting Akt/IKK/NF-κB pathway	[104]
miR-139-5p	SAT	Playing anti- inflammatory effects	[105]
MiR-26a	WAT	Its upregulation/suppression results in reduction/elevation of production of inflammatory cytokines such as TNFα and IL-6	[106]
miR-335	SAT	Upregulated by stimulation of cytokines (leptin, resistin, TNF-α and IL 6), Involved in adipose tissue inflammation	[100]
miR-155	WAT	Involved in the macrophage inflammatory response and progress of chronic inflammation	[107–109]
miR-222	WAT	Correlated with adipocytokines (TNF-α and adiponectin), Targeting CXCL12 in macrophages	[102, 110]
miR-99a	WAT	Blocking the inflammation by targeting mTOR/NF-κB signaling	[111]
miR-125a	SAT	Negative modulator of macrophage-related inflammatory responses	[112]