Table 5.
Inflammatory cytokines and MDA of weaned pigs fed diets with increasing levels of nucleotides (NUC) on day 21
| Item2 | P-value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Nucleotides1, mg/kg | NUC | 0 vs. | ||||||||
| 0 | 50 | 150 | 250 | 500 | SEM | Linear | Quadratic | NUC | 50 + 150 | |
| Plasma | ||||||||||
| TNF-α, pg/mL | 186.1 | 144.7 | 174.6 | 187.8 | 165.5 | 47.1 | 0.996 | 0.640 | 0.418 | 0.226 |
| IL-6, pg/mL | 29.3 | 30.1 | 34.6 | 31.9 | 33.7 | 2.5 | 0.232 | 0.453 | 0.237 | 0.212 |
| MDA, μM/mL | 17.9 | 13.6 | 14.0 | 13.0 | 18.6 | 3.5 | 0.486 | 0.074 | 0.271 | 0.181 |
| Jejunal mucosa | ||||||||||
| TNF-α, pg/g of protein | 3.84 | 3.48 | 3.17 | 3.20 | 5.47 | 0.85 | 0.124 | 0.132 | 0.998 | 0.324 |
| IL-6, pg/g of protein | 3.08 | 2.63 | 2.34 | 3.35 | 2.76 | 0.33 | 0.935 | 0.921 | 0.394 | 0.040 |
| MDA, μM/g of protein | 0.40 | 0.42 | 0.37 | 0.43 | 0.39 | 0.09 | 0.982 | 0.946 | 0.912 | 0.993 |
1Nucleotides were extracted from yeast cell and provided from Hinabiotech (Guangzhou, China).
2TNF-α, tumor necrosis factor- α; IL-6 interleukin-6; MDA, malondialdehyde.