Figure 6.

Oxidative stress and reactive oxygen species and radicals increase the production of ascorbate free radical (AfR) and DHA. DHA is transported by Glut-1/stomatin complex into RBCs where it is intracellularly reduced to AA. This electron pool is used to reduce extracellular AfR molecules and to prevent further production of DHA. The bigger the intracellular electron pool, the more effective is the recycling of extracellular vitamin C due to the independence of this pool from direct glucose uptake and hexose monophosphate pathway