Table 4.

The effects of alpha-lipoic acid supplementation and glucose control and lipid profiles with CI 95% between based on subgroup analysis

Variable		Number of WMD included	Subgroups	Pooled effect estimate	95% CI	I2 (%)	Overall I2 (%)
Glucose	Duration of intervention (weeks)	1	>4 weeks	−16.20	−26.19, −6.21	–	85.0
		2	≤4 weeks	−49.67	−75.95, −23.39	57.5
	Sample size (subjects)	2	≥30 subjects	−38.27	−84.06, 7.52	91.9
		1	<30 subjects	−36.18	−60.58, −11.78	–
Triglycerides	Duration of intervention (weeks)	1	>4 weeks	−18.32	−44.12, 7.48	–	83.9
		3	≤4 weeks	−4.78	−69.74, 60.19	87.6
	Sample size (subjects)	2	≥30 subjects	−47.48	−111.58, 16.61	80.6
		2	<30 subjects	31.08	6.32, 55.85	0.0
Total cholesterol	Duration of intervention (weeks)	1	>4 weeks	−17.92	−35.98, 0.14	–	80.5
		3	≤4 weeks	−24.13	−59.14, 10.88	82.3
	Sample size (subjects)	2	≥30 subjects	−35.42	−68.62, −2.23	88.5
		2	<30 subjects	−6.57	−29.25, 16.10	0.0
LDL-cholesterol	Duration of intervention (weeks)	1	>4 weeks	−14.33	−28.40, −0.26	–	47.4
		3	≤4 weeks	−5.50	−21.44, 10.45	60.3
	Sample size (subjects)	2	≥30 subjects	−17.69	−30.09, −5.29	0.0
		2	<30 subjects	8.45	−11.62, 28.52	0.0
HDL-cholesterol	Duration of intervention (weeks)	1	>4 weeks	10.33	5.78, 14.88	–	85.8
		2	≤4 weeks	−11.40	−21.77, −1.02	0.0
	Sample size (subjects)	1	≥30 subjects	10.33	5.78, 14.88	–
		2	<30 subjects	−11.40	−21.77, −1.02	0.0

CI confidence interval