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. 2019 Nov 6;9(11):1575. doi: 10.3390/nano9111575

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cytotoxicity of mAb-DOXO-functionalized nanoparticles. Real-time toxicity of the not functionalized MNPs, of the MNPs functionalized only with DOXO, or only the mAb or with both DOXO and mAb were performed on the Met/HGF-R+ GTL-16 and on the Met/HGF-R- Huh7 cells. The presence of the DO-24 mAbs significantly increase the toxic activity of the DOXO-functionalized MNPs on GTL-16 cells (a), whereas it had no effect on Huh7 cells (b). Cell index, indicative of cell viability, was measured in a xCELLigence^® assay. CTRL−, control untreated cells. Incubation with not functionalized MNPs gave results similar to those of the control untreated cells.