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Measurements of changes in intercellular adhesion strengths. (a) Experimental design of the measurement system. A cancer cell was picked up using the cup-chip in the AFM, brought closer to another cancer cell, and force measurements were carried out. (b,c) Typical force curves obtained at the separation between two FP10SC2 cells (b) and two MC-FP10SC2 cells (c). (d,e) The boxplots of maximum adhesion forces (d) and separation work (e) of FP10SC2 and MC-FP10SC2 cells. P < 0.01 for (d).
