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. 2019 Dec 16;9:19183. doi: 10.1038/s41598-019-55779-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROS production and cell viability analyzes using the proanthocyanidins-enriched and ethyl acetate fractions from A. crassiflora fruit peel and quercetin in macrophages. Values (mean ± standard deviation) are expressed as relative luminescent units (RLU) for F7 (a), EtOAc (c) and quercetin (e), and area under the curve (AUC) for F7 (b), EtOAc (d) and quercetin (f). (g) Shows cellular viability of macrophages treated with F7, EtOAc and quercetin (10 µg mL⁻¹). Note: F7: proanthocyanidins-enriched fraction, EtOAc: ethyl acetate fraction, Q: quercetin, Med: medium, Zym: zymosan. ^*p < 0.05, ^**p < 0.01 and ^***p < 0.001 versus Zym; ^###p < 0.001 versus Med.