Table 3.
In silico pharmacokinetics proprieties for B-type procyanidins (dimer, trimer, tetramer and pentamer)a.
| Compound | Intestinal absorption (% absorbed) | VDss (log L kg−1) | CYP Inhibitor | Total clearance (log mL min−1 kg−1) | Hepatotoxicity | AMES toxicity |
|---|---|---|---|---|---|---|
| B-type procyanidin (dimer) | 62.436 | −0.046 | No | 0.192 | No | No |
| B-type procyanidin (trimer) | 52.759 | 0 | No | −2.932 | No | No |
| B-type procyanidin (tetramer) | 43.41 | 0.011 | No | −5.074 | No | No |
| B-type procyanidin (pentamer) | 33.737 | 0.011 | No | −7.278 | No | No |
aIntestinal absorption, steady state volume of distribution (VDss), cytochrome P enzymes (CYP) inhibition, total clearance, hepatotoxicity and mutagenicity (AMES) analysis. Cytochrome P enzymes: CYP1A2, CYP2C19, CYP2C9, CYP2D6 and CYP3A4.