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. 2019 Dec 16;9:19140. doi: 10.1038/s41598-019-55745-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cytosolic Ca²⁺ levels, releasable Ca²⁺ from the SR, and total cellular Ca²⁺ levels. (a) Cytosolic Ca²⁺ levels at rest were measured in R429C-expressing myotubes, and the mean values are summarized as histograms. (b) Releasable Ca²⁺ from the SR to the cytosol was measured by treatment with TG (2.5 μM) in the absence of extracellular Ca²⁺. (c) Total cellular Ca²⁺ levels were measured by treatment with ionomycin (5 μM) in the absence of extracellular Ca²⁺. A representative trace for each group is shown in. (b,c) The normalized mean values of each to the mean value of the control are summarized as histograms on the right-hand side. The values are presented as the mean ± s.e.m. for the number of myotubes shown in parentheses in Table 1. *Significant difference compared with the control (p < 0.05).