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. 2019 Dec 16;10:5719. doi: 10.1038/s41467-019-13671-8

Fig. 6. The HDAC3 inhibitor improved mouse oocyte maturation and developmental competence.

Fig. 6

a The GVBD ratios were similar in the control and HDACi 4b groups. HDACi 4b, HDAC3 inhibitor. b More MII-stage oocytes were present in the HDACi 4b group than in the control group. Data are presented as mean ± SEM. Asterisks (*) indicate significant differences at ***P = 0.0002 determined by the two-sided t test. c The blastocyst rate of all GV stage oocytes was considerably increased in the HDACi 4b group compared with the control group. Data are presented as mean ± SEM. Asterisks (*) indicate significant differences at ***P = 0.0006 determined by the two-sided t test. d Representative images show blastocysts obtained from the control and HDACi 4b groups. Scale bars = 100 µm and 40 µm (enlarged). n = 3 biologically independent experiments. e, f Blastocysts from the control and HDACi 4b groups were transferred into surrogate mice. e Birth rates of the control and HDACi 4b groups. f Representative images depicting the pups born in the control and HDACi 4b groups. g The birth weights of the pups in the control and HDACi 4b groups were similar. The data are presented as the mean ± SEM. Source data are provided as a Source Data file.