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. 2019 Dec 16;9:19201. doi: 10.1038/s41598-019-55590-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Percentage of exon-level eQTLs that are trans-acting for all regions on selected chromosomes. Transcript Chr 19, 20, 21 and X were chosen to demonstrate the significant interaction between region and chromosome on the percentage of exon-level trans-acting eQTLs. For example, across the four chromosomes, the putamen (PUTM) shows a constantly high percentage of trans-acting eQTLs (also seen in (b) while the substantia nigra (SNIG) has more variability, high on transcript Chr 19 and X but none on transcript Chr 20 and 21. Transcript Chr X shows a high percentage of trans-acting eQTLs for all regions, highlighting what was shown in (a).