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. 2019 Dec 16;9:19201. doi: 10.1038/s41598-019-55590-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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eQTL effect sizes for cis- versus trans-acting by transcript chromosome at (a) transcript-level and (b) exon-level. These are the absolute values of effect sizes for cis- and trans-acting eQTLs by chromosomes. On average, the absolute values of trans-acting eQTL effect sizes are larger than that of cis-acting eQTLs. This can be seen more clearly at the transcript-level (a) than at the exon-level (b). Note that the eQTLs used for these plots are all the eQTLs found at the transcript-level and exon-level respectively. There are some chromosomes where the absolute effect sizes of cis-acting eQTLs are larger than that of the trans-acting: transcript Chr 6, 17 and 22 at the transcript-level and transcript Chr 1, 2, 9, 16 and 22 at the exon-level. Transcript Chr 16 showed a large increase in cis-acting effect sizes going from the transcript-level to the exon-level.