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. 2019 Dec 16;9:19201. doi: 10.1038/s41598-019-55590-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Estimated effects sizes of (a) transcript-level and (b) exon-level multi-region eQTLs. These are the regression coefficients of the MR-eQTLs found at the transcript-level and at the exon-level. Each line is an MR-eQTL with the points representing the effect size for a brain region. These are sorted from the lowest to the highest mean eQTL effect size with cis-acting MR-eQTLs in black and trans-acting MR-eQTLs in red. The plots also highlight the much smaller proportion of trans-acting MR-eQTLs in both transcript- and exon-levels.