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. 2019 Dec 16;10:5721. doi: 10.1038/s41467-019-13703-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Immediate post-training functional disconnection between the vSUB and the VS with AP-5 (n = 10), impaired spatial memory consolidation compared to vehicle controls (n = 9) (two-way ANOVA of quadrant preference F_3,51 = 15.824; p = 0.0001; treatment F_1,17 = 0.270; p = 0.6100; quadrant × treatment F_3,51 = 4.104; p = 0.0110). The insert shows first bearing of mice in the two groups (t₁₇ = 3.450; p = 0.0031; unpaired t-test). Bottom panels: representative path from vehicle and AP-5 animals. b Unilateral post-training AP-5 (n = 10) administrations in the vSUB and in the ipsilateral VS did not impair mice ability to locate the platform compared to vehicle-injected mice (n = 11) (two-way ANOVA of quadrant preference F_3,57 = 20.775, p = 0.0001; treatment F_1,19 = 1.077, p = 0.3124; quadrant preference × treatment F_3,57 = 0.499, p = 0.6846). The insert shows first bearing of mice in the two groups (t₁₉ = 0.709; p = 0.4871; unpaired t-test). Bottom panels: representative path from vehicle and AP-5 animals. c Immediate post-training vSUB–VS functional disconnection (n = 9) impaired mice ability to discriminate spatial displacement 24 h after training, compared to vehicle-injected mice (n = 15) (vehicle: session × objects F_1,8 = 5.34, p = 0.036; AP-5: session × objects F_1,14 = 0.37; p = 0.55). Histograms represent mean ± SEM; *p < 0.05 displaced objects (DO) in S5 vs DO in S4 (within group, Fisher). d Post-training functional disconnection between vSUB and VS (n = 9) did not affect mice ability to locate the platform 24 h after training in the cMWM (vehicle n = 8) (two-way ANOVA of quadrant preference F_3,45 = 14.814; p = 0.0001; treatment F_1,15 = 1.134; p = 0.3037; quadrant preference × treatment F_3,45 = 0.369; p = 0.7754). The insert shows first bearing of mice in the two groups (t₁₅ = 0.299; p = 0.7692; unpaired t-test). Bottom panels: representative path from vehicle and AP-5 animals. Histograms represent mean ± SEM; *p < 0.05 target vs right, opposite, left (within group); ^#p < 0.05 target vs target (between groups, Tukey). MWM images modified from ref. ⁹; Image credit for brains schematics: Allen Institute.