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. 2019 Dec 16;9:19213. doi: 10.1038/s41598-019-55720-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network depiction of significant associations between endometrial cancer and ECbiome (17 taxa associated with endometrial cancer). In this network, nodes represent OTUs and clinical covariates; edges link either (i) an OTU with its statistically-associated clinical factor, or (ii) correlated OTUs found using SparCC on the entire OTU compositional (i.e. relative abundances) table. Eight of the 17 ECbiome taxa are independently enriched by postmenopause, which is depicted in this figure to clarify relationships. The microbe most strongly associated with endometrial cancer (P. somerae) is not associated with postmenopause. Species-level annotation for each OTU was determined by identifying its phylogenetically closest bacterial genome using BLAST.