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. 2019 Dec 16;9:19161. doi: 10.1038/s41598-019-55605-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Investigation of the C-PC and radiation beams synergistic effects on the cancer and normal cells viability at different concentrations of C-PC (50, 100, and 200 µg/mL) and different radiation therapy dosages (2,4, and 6 Gy) by MTT assay and CompuSyn software. (A) Three different colon cancer cell lines including CT-26, DLD-1, HT-29 and CRL-1831 as the normal colonic cell line were used. (The first columns from the left side of the MTT assay charts exhibit the cell viability of the wells which were incubated with 0 µg/mL C-PC as the control (no-treatment). Also, the cell viability of the wells which were mono-treated with 2, 4, and 6 Gy radiation was illustrated in the 2^nd, 3^rd, and 4^th column from the left side of the MTT assay charts to exhibit the effect of radiation therapy mono-treatment on the cancer cells viability (*P < 0.05, ns: not significant). (B) To investigate, the synergistic effect of radiation therapy and C-PC co-treatment. The combination index (CI) was calculated by analyzing the MTT assay data for different cell lines using CompuSyn software. CI < 1, CI = 1, and CI > 1 stand for synergistic, additive, and antagonistic effects, respectively. Also, Fa refers to inhibitory rate.