Figure 6.

ESAM Expression on HSCs Directly Influenced Their Quality

E14.5 WT FL-derived LSK CD48^– cells were either untreated (ESAM minus) or incubated with a rat monoclonal antibody against mouse ESAM (ESAM plus). The extracted RNA samples were used to conduct RNA-seq and bioinformatic analyses by Ingenuity Pathway Analysis (IPA).

(A) Top 5 networks affected in this experiment are shown.

(B) The IPA network scores of each network described in (A) are shown in a horizontal bar graph. Scores indicate the negative exponent of the p value which is based on the hypergeometric distribution and is calculated with the Fisher's exact test.

See also Figure S4.